Hi Gino, John and Doves,
Gino - your thought provoking post linked below. SUCH a good question!! The Euphrates is in the Middle East, as we know. Israel's eastern neighbours want to destroy Israel ' from the river to the sea'. Which river does that refer to? The Euphrates, of course! The end-times enemies of Israel are her Muslim neighbours. Well spotted, Gino.
How, after 15 times does the meaning change at the end? (fivedoves.com)