I have wondered if part of God's judgement of Eve was to have
"hundreds"  of children.
   And that Adam's judgement was to have to deal with all that! 
Hebrew scholars suggest that over a couple hundred years she had fifty
children. However, that number could have been far larger, as they
both lived maybe 800 years!
>From "Christianity" site, their analysis:

Assuming that:
    Adam only had one wife (Eve), which is an argument based strictly
on a lack of evidence.
That Eve's normal gestational period was 9 months and had twins no
more than average (1 in 86).
   That Eve lived approximately the same amount of time as Adam (again
an argument from lack of evidence),

then we can say:

800 years / 9 months per child (assuming no rest between children) =
1000 ...  ouch ...
Twins appear in 1 out of every 86 births = 11
           I think we can then establish an upper limit for Adam and
Eve having a maximum of 1011 children.
      Beyond that, one can only speculate.
I am sure all the mothers are shaking their heads on all this 
Lewis