Meaning of Great Sign in Heaven Rev. 12

The virgin with garland of 12 stars is Israel.

The man-child is Jesus.

The  great red dragon, having seven heads and ten horns, and seven crowns upon his heads is the Roman Empire that had control over Israel and it’s surrounding nations when Jesus walked the Earth; now in the form of the Roman Catholic Church with has a concordat ( an agreement or treaty, especially one between the Vatican and a secular government relating to matters of mutual interest) with the same nations (same area of said nations under new names). This great red dragon (beast) is ridden by:
 Rev 17:4  And the woman was arrayed in purple and scarlet colour, and decked with gold and precious stones and pearls, having a golden cup in her hand full of abominations and filthiness of her fornication:
Rev 17:5  And upon her forehead was a name written, MYSTERY, BABYLON THE GREAT, THE MOTHER OF HARLOTS AND ABOMINATIONS OF THE EARTH.
Rev 17:6  And I saw the woman drunken with the blood of the saints (millions of reformation saints), and with the blood of the martyrs of Jesus: and when I saw her, I wondered with great admiration.
Rev 17:7  And the angel said unto me, Wherefore didst thou marvel? I will tell thee the mystery of the woman, and of the beast that carrieth her, which hath the seven heads and ten horns.

 Paul calls Rome by the name of Babylon.
1 Peter 5:13  The church that is at Babylon, elected together with you, saluteth you; and so doth Marcus my son.
Rev 17:9  And here is the mind which hath wisdom. The seven heads are seven mountains, on which the woman sitteth. (Rome sits on 7 hills/mountains)


The man-child that is caught up to heaven  upon birth is Jesus coming for His bride. His feet do not touch the Earth. He catches up His bride and returns to heaven. In a blink of an eye, we are caught up with Jesus unto heaven. Upon His birth her child was caught up unto God, and to his throne. In a blink of an eye!

Rev 12:5  And she brought forth a man child, who was to rule all nations with a rod of iron
denotes the beginning of the tribulation with Jesus dealing with the Earth directly ordering His angels to bring forth the 7 seals, 7 trumpets,  7 thunders and woes; bringing forth judgment upon the nations/peoples who rejected Him. The population of the Earth is about 7.6 billion, of these 1/4 are killed....and 1/3rd are killed and at Armageddon the blood flows to the depth of the bridle of a horse.  Approx. 75% are killed +/-.

Rev 12:6  And the woman fled into the wilderness, where she hath a place prepared of God, that they should feed her there a thousand two hundred and threescore days.  The woman (the virgin Israel) is taken care of (by  God) during the tribulation (protected and taken care of) for 3 1/2 years.