Fulfilled? Yes and no :)We have the law of DOUBLE reference....As in much of prophecy, the latter chapters of Daniel gave a blow by blow prophetic picture of the events of the Greek kings oppressing the Hebrew people. These prophecies were fulfilled to the letter which is why liberal scholars try to late Daniel till after these events.These chapters/verses apply both to the ancient mad Greek king and to the AntiChrist---- the AntiChrist will REPEAT the abomination of mad Greek king in the holy place bringing judgment upon himself and after that Messiah will return.
Dan 11:36 And the king shall do according to his will; and he shall exalt himself, and magnify himself above every god, and shall speak marvelous things against the God of gods, and shall prosper till the indignation be accomplished: for that that is determined shall be done.
Dan 11:37 Neither shall he regard the God of his fathers, nor the desire of women, nor regard any god: for he shall magnify himself above all.Lewis Brackett