I do not know why I have not seen the profound significance of the Lord's first miracle before, but I believe that He has shown me a powerful connection between this and His return for His Bride.
 
First, we see the Lord at a wedding feast.  He reveals Himself as Messiah at this wedding.  How? He gives the guests at the wedding purifying wine (remember the wine came out of the vessels made for purification rituals) made from water.  Jesus told us to drink wine to remember the blood He shed for us.  So who were the ones who participated in drinking of this wine that the Lord gives?  It was those who were invited to the wedding.
 
There are a couple of other interesting things that I noticed here and I am sure that together we will discover more, but initially I thought all of the disciples were at the wedding with Him, but when I went back and counted, I could count only five.  Which is interesting because of the parable of the ten virgins.
 
The headwaiter also said that this wine was better than that served in the beginning.  To me, it was declaring that the second covenant was better than the first.
 
Also, this explains Jesus' response to Mary when He told her 'what does this have to do with me, my time has not yet come'.  He was talking about His cross, and the time for the true wine (blood) had not yet come.
 
The really interesting thing to note is the timing of this wedding feast.  The scripture says 'on the third day' this wedding feast occurs.  If you go back to the previous chapter, you see Jesus gathering some disciples Himself and you also see some of the disciples gathering other disciples.  Very much like what has been happening the 'two days' (two thousand years) since Jesus left the Earth.  As a prophetic foreshadowing of events to come, scripture tells us what was happening the two days prior to the wedding feast, which occurred on the third day.  BUT there is one last thing that I believe all of you would find interesting ... and that is scripture says that this wedding feast took place just a few days before passover.